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Index > Protein center > Eif2ak3(Gene name) > Mouse
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  • Eif2ak3 (Gene name),
  • Eukaryotic translation initiation factor 2-alpha kinase 3 (Protein name ),  E2AK3_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Eif2ak3(Pek;Perk);
    Protein name:
    Eukaryotic translation initiation factor 2-alpha kinase 3;
    Alternative:
    Pancreatic eIF2-alpha kinase;PRKR-like endoplasmic reticulum kinase;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Forms dimers with HSPA5/BIP in resting cells. Oligomerizes in ER-stressed cells. Interacts with DNAJC3.
    Function:
    Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1.
    Subcellular Location:
    Endoplasmic reticulum membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1114
    Sequence:
    50:
    MERATRPGPR | ALLLLLFLLL | GCAAGISAVA | PARSLLAPAS | ETVFGLGAAA | 
    100:
    APTSAARVPA | VATAEVTVED | AEALPAAAGE | PESRATEPDD | DVELRPRGRS | 
    150:
    LVIISTLDGR | IAALDAENDG | KKQWDLDVGS | GSLVSSSLSK | PEVFGNKMII | 
    200:
    PSLDGDLFQW | DRDRESMEAV | PFTVESLLES | SYKFGDDVVL | VGGKSLITYG | 
    250:
    LSAYSGKLRY | ICSALGCRRW | DSDEMEEEED | ILLLQRTQKT | VRAVGPRSGS | 
    300:
    EKWNFSVGHF | ELRYIPDMET | RAGFIESTFK | PGGNKEDSKI | ISDVEEQEAT | 
    350:
    MLDTVIKVSV | ADWKVMAFSR | KGGRLEWEYQ | FCTPIASAWL | VRDGKVIPIS | 
    400:
    LFDDTSYTAS | EEALGDEEDI | VEAARGATEN | SVYLGMYRGQ | LYLQSSVRVS | 
    450:
    EKFPTSPKAL | ESVNGENAII | PLPTIKWKPL | IHSPSRTPVL | VGSDEFDKCL | 
    500:
    SNDKYSHEEY | SNGALSILQY | PYDNGYYLPY | YKRERNKRST | QITVRFLDSP | 
    550:
    HYSKNIRKKD | PILLLHWWKE | IFGTILLCIV | ATTFIVRRLF | HPQPHRQRKE | 
    600:
    SETQCQTESK | YDSVSADVSD | NSWNDMKYSG | YVSRYLTDFE | PIQCMGRGGF | 
    650:
    GVVFEAKNKV | DDCNYAIKRI | RLPNRELARE | KVMREVKALA | KLEHPGIVRY | 
    700:
    FNAWLETPPE | KWQEEMDEIW | LKDESTDWPL | SSPSPMDAPS | VKIRRMDPFS | 
    750:
    TKEQIEVIAP | SPERSRSFSV | GISCGQTSSS | ESQFSPLEFS | GTDCGDNSDS | 
    800:
    ADAAYNLQDS | CLTDCEDVED | GTVDGNDEGH | SFELCPSEAS | PYTRSREGTS | 
    850:
    SSIVFEDSGC | GNASSKEEPR | GNRLHDGNHY | VNKLTDLKCS | SSRSSSEATT | 
    900:
    LSTSPTRPTT | LSLDFTKNTV | GQLQPSSPKV | YLYIQMQLCR | KENLKDWMNR | 
    950:
    RCSLEDREHG | VCLHIFLQIA | EAVEFLHSKG | LMHRDLKPSN | IFFTMDDVVK | 
    1000:
    VGDFGLVTAM | DQDEEEQTVL | TPMPAYATHT | GQVGTKLYMS | PEQIHGNNYS | 
    1050:
    HKVDIFSLGL | ILFELLYPFS | TQMERVRILT | DVRNLKFPLL | FTQKYPQEHM | 
    1100:
    MVQDMLSPSP | TERPEATDII | ENAIFENLEF | PGKTVLRQRS | RSMSSSGTKH | 
    1114:
    SRQPSCSYSP | LPGN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Eukaryotic translation initiation factor 2-alpha kinase 3
    Cat.:
    E11434h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Eukaryotic translation initiation factor 2-alpha kinase 3
    Cat.:
    E11434m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Eukaryotic translation initiation factor 2-alpha kinase 3
    Cat.:
    E11434r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Eukaryotic translation initiation factor 2-alpha kinase 3
    Cat.:
    U11434h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Eukaryotic translation initiation factor 2-alpha kinase 3
    Cat.:
    U11434r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Eukaryotic translation initiation factor 2-alpha kinase 3
    Cat.:
    U11434m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Eukaryotic translation initiation factor 2-alpha kinase 3
    Cat.:
    P11434Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Eukaryotic translation initiation factor 2-alpha kinase 3
    Polyclonal Antibody for Mouse Eukaryotic translation initiation factor 2-alpha kinase 3
    Monoclonal Antibody for Mouse Eukaryotic translation initiation factor 2-alpha kinase 3
    Monoclonal Antibody for Mouse Eukaryotic translation initiation factor 2-alpha kinase 3
    Monoclonal Antibody for Mouse Eukaryotic translation initiation factor 2-alpha kinase 3
    Protein for Mouse Eukaryotic translation initiation factor 2-alpha kinase 3
    Protein for Mouse Eukaryotic translation initiation factor 2-alpha kinase 3
    Protein for Mouse Eukaryotic translation initiation factor 2-alpha kinase 3

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase."
      Harding H.P. , Zhang Y. , Ron D.
      Nature397:271-274(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];MUTAGENESIS OF LYS-618
      strain: NIH Swiss.
      tissue: Fibroblast.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-152 AND 769-1114
      strain: C57BL/6J.
    4. 4.
      "Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response."
      Bertolotti A. , Zhang Y. , Hendershot L.M. , Harding H.P. , Ron D.
      Nat. Cell Biol.2:326-332(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
    5. 5.
      "PERK mediates cell-cycle exit during the mammalian unfolded protein response."
      Brewer J.W. , Diehl J.A.
      Proc. Natl. Acad. Sci. U.S.A.97:12625-12630(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      "Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK."
      Yan W. , Frank C.L. , Korth M.J. , Sopher B.L. , Novoa I. , Ron D. , Katze M.G.
      Proc. Natl. Acad. Sci. U.S.A.99:15920-15925(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DNAJC3
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MFN2
    8. 8.
      "The structure of the PERK kinase domain suggests the mechanism for its activation."
      Cui W. , Li J. , Ron D. , Sha B.
      Acta Crystallogr. D67:423-428(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF 583-701 AND 867-1078;SUBUNIT;PHOSPHORYLATION AT THR-980
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